Mating-type switching and mating-type gene array expression in the methylotrophic yeast Ogataea thermomethanolica TBRC656
نویسندگان
چکیده
منابع مشابه
Flip/flop mating-type switching in the methylotrophic yeast Ogataea polymorpha is regulated by an Efg1-Rme1-Ste12 pathway
In haploid cells of Ogataea (Hansenula) polymorpha an environmental signal, nitrogen starvation, induces a reversible change in the structure of a chromosome. This process, mating-type switching, inverts a 19-kb DNA region to place either MATa or MATα genes under centromeric repression of transcription, depending on the orientation of the region. Here, we investigated the genetic pathway that c...
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The study of yeast mating-type (MAT) gene switching has provided insights into several aspects of the regulation of gene expression. MAT switching is accomplished by a highly programmed site-specific homologous recombination event in which mating-type-specific sequences at MAT are replaced by alternative DNA sequences copied from one of two unexpressed donors. The mating-type system has also pr...
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Saccharomyces cerevisiae, baker’s yeast, can exist in either a haploid (1n) or a diploid (2n) state. Haploids express one of two mating types, a or a (alpha). Haploids of either mating type are capable of mating with haploids of the opposite mating type in response to the action of mating pheromones. Mating results in fusion of haploid cells, forming an a/a diploid, which is no longer capable o...
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It has been 33 years since I first presented results of genetic experiments that established the gene transposition model as the mechanism of mating-type switching in the budding yeast Saccharomyces cerevisiae at the Cold Spring Harbor Laboratory (CSHL) Yeast Genetics meeting in August 1977. Over two decades ago the Genetics Perspectives editors solicited a perspective on my participation in th...
متن کاملRegulation of yeast mating-type interconversion: feedback control of HO gene expression by the mating-type locus.
The ultimate product of yeast mating-type interconversion is a stable a/alpha diploid cell. A haploid cell carrying the HO gene gives rise to a diploid cell in a two-step process: first, the cell switches mating type as a result of genetic rearrangement (cassette substitution) catalyzed by HO; then, cells of opposite type mate to form a/alpha diploids. Mating-type interconversion does not occur...
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ژورنال
عنوان ژورنال: Microbiological Research
سال: 2020
ISSN: 0944-5013
DOI: 10.1016/j.micres.2019.126372